An alkaloid isolated from the corn lily (Veratrum californicum) is a Sonic Hedgehog gene pathway antagonist with potential anticancer properties
- Catalog No: APH-05015
- CAS Number: 23185-94-6
- Chemical Formula: C33H51NO7
- Molecular Weight: 573.77
- Purity: > 98 % determined by CP HPLC
- Appearance: White to off-white crystalline solid
- Solubility: Soluble in methanol.
- Stability: Stable under recommended storage conditions.
- Storage: -20°C
- Shipping: On ice (5°C)
- Handling: Avoid exposure to skin and eyes.
Cycloposine is a steroidal alkaloid isolated from the corn lily (Veratrum californicum) that grows wild in the mountains and deserts of Nevada and California.
Cycloposine is the glycoside of cyclopamine (Riet-Correa, 2011). Cycloposine, jervine and cyclopamine are three compounds identified in V. californicum that cause cyclopism in lambs whose mothers ingested the plant during pregnancy (Keeler 1968).
Aphios isolates and manufactures cycloposine utilizing near-critical and supercritical fluids using CXF and CXP enabling technology platforms followed by proprietary segmentation chromatography.
Certain biological properties of cycloposine are similar to those of cyclopamine.
Keeler R and Binns W. (1968) Teratogenic compounds of Veratrum californicum (Durand). V. Comparison of cyclopian effects of steroidal alkaloids from the plant and structurally related compounds from other sources. Teratology. 1, 5-10.
Riet-Correa F. (2011) Poisoning by Plants, Mycotoxins and Related Toxins. 244.