A New Standard in Mental Health Innovation
The Anxiety Epidemic
Anxiety disorders are the most common mental health condition worldwide, affecting nearly 1 in 5 American adults and 1 in 3 adolescents each year. The COVID-19 pandemic has intensified this crisis, driving a 25% global increase in anxiety and depression. Current treatments—such as antidepressants and benzodiazepines—offer limited relief, often come with adverse side effects, and are only effective in 40–60% of patients.
The Promise of Cannabidiol (CBD)
CBD, a non-psychoactive component of Cannabis sativa, has demonstrated powerful anxiolytic effects in both preclinical and clinical studies. It interacts with serotonin (5-HT1A) and cannabinoid (CB1) receptors to regulate fear and anxiety behaviors. However, conventional oral CBD has very low bioavailability (~6%) and requires large doses for therapeutic benefit.
Our Innovation: Extended-Release Nano-CBD
Aphios Pharma is developing a once-daily, extended-release CBD capsule using our patented SuperFluids™ Polymer Nanospheres (SFS-PNS™) technology. This nanotechnology encapsulates CBD in biodegradable polymer spheres, protecting it from stomach acid and liver metabolism, while enabling controlled release and improved absorption in the gut.
Key Advantages
- 5x Higher Bioavailability: Delivers more active CBD to the bloodstream
- Reduced Dose: From 400–800 mg/day to just 80–160 mg/day
- Lower Cost: ~2.5x savings for patients over current oil-based CBD products
- No Toxic Solvents: Uses supercritical fluids, not hazardous organics
- Enhanced Stability & Sterility: SFS-PNS™ ensures clean, scalable production
Better Science. Better CBD.
Unlike standard formulations, our SFS-PNS™ process avoids toxic solvent residues and produces sterile, stable nanoparticles. It has been successfully applied to Δ9-THC, insulin, and other difficult-to-deliver drugs. This next-generation CBD formulation is designed to enhance patient adherence, reduce side effects, and offer real relief—naturally.
A Once-Daily Solution for Chronic Anxiety
With a single daily capsule, patients can experience sustained anxiety relief without the sedation, dependency, or tolerance associated with traditional anti-anxiety medications. Our product is designed for those seeking a safer, more effective path to emotional well-being.
Join Us in Transforming Mental Health
Aphios Pharma is leading the charge in natural, nanotech-enabled therapeutics. Our CBD innovation represents a scalable, environmentally responsible approach to anxiety treatment with broad potential across CNS disorders.