10-Deacetylbaccatin III (10-DAB)

A paclitaxel intermediate isolated from the Yew Tree (Taxus sp.)

  • Catalog No: APH-93083
  • CAS Number: 32981-86-5
  • Chemical Formula: C29H36O10
  • Molecular Weight: 544.6
  • Purity: > 99 % determined by CP HPLC
  • Appearance: White solid
  • Solubility: Soluble in DMSO, methanol, ethanol, acetonitrile. Insoluble in water.
  • Stability: Stable under recommended storage conditions.
  • Storage: Store in a tightly closed container at 2 to 8°C.
  • Shipping: On ice (5°C)
  • Handling: Avoid heat and exposure to direct sunlight.

Research Chemicals 10-DAB Molecular Structure  


Research Chemicals  10-DAB Taxus Yew Farm10-deacetylbaccatin III (10-DAB) is the fifth intermediate in the biosynthetic pathway of paclitaxel in Taxus species (Walker, 2000).

At Aphios, 10-DAB is isolated from the needles (leaves) and roots of the Canadian Yew tree, Taxus canadensis, the American ornamental Yew Tree, Taxus media "hicksii" or the European Yew Tree, Taxus baccata, utilizing patented SuperFluids™CXP technology [Castor, US Patent] followed by segmentation chromatography. 10-DAB is used as the core starting material in the semi-synthetic manufacturing of paclitaxel [Holton, 1991]. 10-DAB is also used as the starting raw material for docetaxel (Taxotere®), a potent anticancer compound.

Biological Activity:

10-deacetylbaccatin III is an intermediate in the biosynthetic pathway of the taxane, paclitaxel. Taxanes disrupt mitosis by preventing microtubule destabilization and spindle fiber formation in animal cells (Molè-Bajer, 1983). As a consequence of this mechanism, yew trees are slow growing organisms. Without mitosis, cells, especially cells with a high replication rate such as tumor cells, cannot divide. Taxanes are currently being investigated as possible treatment for certain cancers, and paclitaxel, is currently approved by the FDA for treatment of AIDS-related Karposi sarcoma, breast cancer, non-small cell lung cancer, and ovarian cancer (National Cancer Institute, 2012).


Holton R. (1991) Method for preparation of taxol using an oxazinone. US Patent 5,015,744.

Walker K and Croteau R. (2000) Taxol biosynthesis: molecular cloning of a benzoyl-CoA:taxane 2alpha-O-benzoyltransferase cDNA from taxus and functional expression in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 97(25), 13591-13596.

Elmer W, Mattina M and MacEachern G. (1994) Sensitivity of plant pathogenic fungi to taxane extracts from ornamental yews. Phytopathology. 84(10), 1179-1185.

Molè-Bajer J and Bajer A. (1983) Action of Taxol on Mitosis: Modification of Microtubule Arrangements and Function of the Mitotic Spindle in Haemanthus Endosperm. Journal of Cell Biology. 96, 527-540.

National Cancer Institute. (2012) Cancer Drug Information: Paclitaxel. www.cancer.gov.

MSDS Sheet

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